In
clinical trials the demand for genotype data on the phase I and phase II drug
metabolism enzymes is increasing. To accommodate these developments in the marketplace,
we are offering two distinct levels of service.
a. Premium Geneblitz® genotyping:
Genotype designation for the phase I and phase II enzymes indicated in the
table below. Please feel free to call or e-mail us to discuss your specific
requirements. The price we quote to you will depend upon: a) the complexity
of the assay required, b) the number of alleles for which a genotype designation
is needed and c) the number of patient samples. A full service, performed to
BS EN ISO9001:2000, including sample tracking, DNA preparation, quantitation
and storage, will be quoted if this is required by yourselves.
b. Regulatory
Geneblitz® genotyping:
Our regulatory Geneblitz® genotyping service offers the additional option
of assay validation to ICH guidelines Q2A and Q2B (specificity, accuracy, precision,
detection limit and robustness). We develop the programme of work according
to client's requirements and to an agreed project management schedule.
Phase I enzymes
| Gene | Designated alleles | In house assay? |
| CYP1A1 | *1A, B, C *2A, B, C *3 *4 *5 *6 | Yes |
| CYP1A2 | *1A to H *2 *3 *4 *5 *6 | Yes |
| CYP1B1 | *1 to *7 *11 to *26 | Yes |
| CYP2A6 | *1 *2 *3 *4A to D *5 to 11 | Yes |
| CYP2B6 | *1 to *7 | Yes |
| CYP2C8 | *1A, B, C, *2 *3 *4 | Yes |
| CYP2C9 | *1 to *6 | Yes |
| CYP2C1 | *1A, B *2A, B, *3, *4, *5A, B *6 to *8 | Yes |
| CYP2D6 | Please enquire | - |
| CYP2E1 | *1 A to D *2 to *7 | Yes |
| CYP2J2 | *1 to *7 | Yes |
| CYP3A4 | Please enquire | - |
| CYP3A5 | *1 to *7 | Yes |
| CYP3A7 | *1A to E | Yes |
| CYP4B1 | *1 to *5 | Yes |
| CYP5A1 | *1 to *9 | Yes |
| CYP8A1 | *1A to L *2 *3 *4 | Yes |
| CYP21 | *1 to *59 | Yes |
Phase II enzymes
| Gene | Designated alleles | In house assay? |
| GST-M1 | Gene
deletion Gene duplication |
Yes Yes |
| GST-T1 | Gene deletion | Yes |
| GST-P1 | *A *B *C | Yes |
| NAT-1 | *3 *4 *5 *10 *11 *14 to *29, | Yes |
| NAT-2 | *4 *5 *6 *7 *10 to *14 *17 to *19 | Yes |
| EPHX-1 | Tyr 113 His | Yes |
Please click here for further information on the phase I and phase II enzymes.
We also offer the following services
Residual DNA
Genotyping
Forensic Testing,
Gene Expression
DNA sequencing
Quantitative PCR
Gene cloning and expression
DNA preparation
Contract research
ELISA and Western Blotting
Animal identity testing
Microarray technology
Human / Cell line identity testing
We are reliable, responsive and cost effective. Contact 0191 516 6500 or email sales@geneblitz.com for a discussion of your requirements.
Website designed and maintained
by