The Geneblitz® genotyping service offers an extensive range of assays designed to complement drug discovery, research and clinical trial programmes.
Our portfolio of genotyping assays is increasing rapidly and we are always pleased to hear of your genotyping requirements. If you require an assay, which is not on our current list, then please contact us.
The Geneblitz® genotyping service offers you any or all of three options:
1.
Saturation Polymorphism Analysis
We
undertake, on your behalf, a systematic analysis of DNA sequence variation in
candidate genes or genomic regions in any ethnically diverse or specified population
group. To do this, we will work with you to obtain any number of consented genomic
DNA samples, will amplify the gene or DNA region of interest and will identify
DNA polymorphisms therein. From these data we determine the haplotypes
which occur in the population studied or can identify differences between normal
and tumour tissue. When combined with our TaqMan® based transcriptional
profiling system, you have access to a powerful set of tools for assisting with
your drug development and research programmes.
Projects are priced on a contract research basis (daily, monthly or yearly rate) whereby we discuss with you the work required and carry it out to your specification. Please email us on sales@geneblitz.com to request further information. More details can also be found on the Contact page.
2. Disease Specific Genotyping
This particular Geneblitz® genotyping
service specialises in SNP analyses and identification in disease specific genes
or disease associated regions of the genome. Our portfolio includes analysis
for cancer associated genetic polymorphisms and those markers which predict
the toxicity and efficacy of chemotherapeutic drugs.
We also offer a range of tests associated with prediction of heart disease and rejection of organs after transplantation. Other assays involve, for example, SNP's as markers for neurological disorders. We are always pleased to consider new assays and would be keen to hear your requirements.
Please click here for further information on cancer genotyping assays
3. Pharmacogenetic Profiling - Drug
Metabolism
That individuals respond in a different manner
to equivalent doses of the same drug is a well-known phenomenon.
In mammals, the metabolism of xenobiotics is catalysed by the phase I (oxidation) and phase II (conjugation) enzyme systems.
The Geneblitz® service is designed to assist you with the process of understanding the genetic profiles of patients enrolled in phase I to phase IV clinical trials, by determination of DNA polymorphisms associated with the phase I and phase II enzymes. Our portfolio of pharmacogentic genotyping assays is substantial and we would be pleased to discuss your needs with you.
Please click here for details of our pharmacogenetic profiling services.
Please click here for further information on drug metabolism.
We also offer the following services
Residual DNA
Genotyping
Forensic Testing,
Gene Expression
DNA sequencing
Quantitative PCR
Gene cloning and expression
DNA preparation
Contract research
ELISA and Western Blotting
Animal identity testing
Microarray technology
Human / Cell line identity testing
We are reliable, responsive and cost effective. Contact 0191 516 6500 or email sales@geneblitz.com for a discussion of your requirements.
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