| Genotyping including Polymorphism
Screening
The
Geneblitz® genotyping service offers an extensive range of assays
designed to complement drug discovery, research and clinical trial
programmes.
Our
portfolio of genotyping assays is increasing rapidly and we are
always pleased to hear of your genotyping requirements. If you require
an assay, which is not on our current list, then please contact
us.
The
Geneblitz® genotyping service offers you any or all of three
options:
- Saturation
Polymorphism Screening and Analysis for haplotype and "drug
to target" determination.
- Disease
Specific Genotyping plus genotyping for other conditions and
characteristics.
-
Pharmacogenetic Profiling; genotyping associated with drug
metabolism (phase I and phase II enzymes).
1.
Saturation Polymorphism Screening and Analysis
We
undertake, on your behalf, a systematic analysis of DNA sequence
variation in candidate genes or genomic regions in any ethnically
diverse or specified population group. To do this, we will work
with you to obtain any number of consented genomic DNA samples,
will amplify the gene or DNA region of interest and will identify
DNA polymorphisms therein. From these data we determine the haplotypes
which occur in the population studied or can identify differences
between normal and tumour tissue. When combined with our TaqMan®
based transcriptional profiling system, you have access to a powerful
set of tools for assisting with your drug development and research
programmes.
Projects
are priced on a contract research basis (daily, monthly or yearly
rate) whereby we discuss with you the work required and carry it
out to your specification. Please email us on sales@geneblitz.com
to request further information. More details can also be found on
the Contact
page.
2. Disease Specific Genotyping
This particular Geneblitz®
genotyping service specialises in SNP analyses and identification
in disease specific genes or disease associated regions of the genome.
Our portfolio includes analysis for cancer associated genetic polymorphisms
and those markers which predict the toxicity and efficacy of chemotherapeutic
drugs.
We also offer a range
of tests associated with prediction of heart disease and rejection
of organs after transplantation. Other assays involve, for example,
SNP's as markers for neurological disorders. We are always pleased
to consider new assays and would be keen to hear your requirements.
Please click here
for further information on cancer genotyping assays
3. Pharmacogenetic Profiling
- Drug Metabolism
That individuals respond in a
different manner to equivalent doses of the same drug is a well-known
phenomenon.
In mammals, the metabolism
of xenobiotics is catalysed by the phase I (oxidation) and phase
II (conjugation) enzyme systems.
The Geneblitz® service
is designed to assist you with the process of understanding the
genetic profiles of patients enrolled in phase I to phase IV clinical
trials, by determination of DNA polymorphisms associated with the
phase I and phase II enzymes. Our portfolio of pharmacogentic genotyping
assays is substantial and we would be pleased to discuss your needs
with you.
Please click here
for details of our pharmacogenetic profiling services.
Please click here
for further information on drug metabolism.
We also offer
services such as Residual
DNA, Genotyping,
Forensic
Testing, Gene
Expression and various
other services. Please click here
to contact us with your requirements.
We are reliable,
responsive and cost effective. Please
contact us now for discussion of your needs.
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