Pharmacogenetics
In clinical trials the demand for genotype data on the phase I and phase II drug metabolism enzymes is increasing. To accommodate these developments in the marketplace, we are offering two distinct levels of service.
a. Premium Geneblitz® genotyping:
Genotype designation for the phase I and phase II enzymes indicated in the table below. Please feel free to call or e-mail us to discuss your specific requirements. The price we quote to you will depend upon: a) the complexity of the assay required, b) the number of alleles for which a genotype designation is needed and c) the number of patient samples. A full service, performed to BS EN ISO9001:2000, including sample tracking, DNA preparation, quantitation and storage, will be quoted if this is required by yourselves.
b. Regulatory Geneblitz® genotyping:
Our regulatory Geneblitz® genotyping service offers the additional option of assay validation to ICH guidelines Q2A and Q2B (specificity, accuracy, precision, detection limit and robustness). We develop the programme of work according to client's requirements and to an agreed project management schedule.
Phase I enzymes
Gene |
Designated alleles |
In house assay? |
CYP1A1 |
*1A, B, C *2A, B, C *3 *4 *5 *6 |
Yes |
CYP1A2 |
*1A to H *2 *3 *4 *5 *6 |
Yes |
CYP1B1 |
*1 to *7 *11 to *26 |
Yes |
CYP2A6 |
*1 *2 *3 *4A to D *5 to 11 |
Yes |
CYP2B6 |
*1 to *7 |
Yes |
CYP2C8 |
*1A, B, C, *2 *3 *4 |
Yes |
CYP2C9 |
*1 to *6 |
Yes |
CYP2C1 |
*1A, B *2A, B, *3, *4, *5A, B *6 to *8 |
Yes |
CYP2D6 |
Please enquire |
- |
CYP2E1 |
*1 A to D *2 to *7 |
Yes |
CYP2J2 |
*1 to *7 |
Yes |
CYP3A4 |
Please enquire |
- |
CYP3A5 |
*1 to *7 |
Yes |
CYP3A7 |
*1A to E |
Yes |
CYP4B1 |
*1 to *5 |
Yes |
CYP5A1 |
*1 to *9 |
Yes |
CYP8A1 |
*1A to L *2 *3 *4 |
Yes |
CYP21 |
*1 to *59 |
Yes |
Phase II enzymes
Gene |
Designated alleles |
In house assay? |
GST-M1 |
Gene deletion
Gene duplication
|
Yes
Yes |
GST-T1 |
Gene deletion |
Yes |
GST-P1 |
*A *B *C |
Yes |
NAT-1 |
*3 *4 *5 *10 *11 *14 to *29, |
Yes |
NAT-2 |
*4 *5 *6 *7 *10 to *14 *17 to *19 |
Yes |
EPHX-1 |
Tyr 113 His |
Yes |
We also offer services such as Residual DNA, Genotyping, Forensic Testing, Gene Expression and various other services. Please click here to contact us with your requirements.
We are reliable, responsive and cost effective.

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