Gene expression studies
Genome Wide Association studies
Genotyping
Pharmacogenetic screening
Residual DNA testing
Mutagenicity and toxicity testing
Forensic & human identity testing
Animal identity testing
Human stem/cell line testing
DNA sequencing
Nucleic acid isolation
LC/MS/MS
ELISA/Western Blotting

Pharmacogenetics

In clinical trials the demand for genotype data on the phase I and phase II drug metabolism enzymes is increasing. To accommodate these developments in the marketplace, we are offering two distinct levels of service.

a. Premium Geneblitz® genotyping:

Genotype designation for the phase I and phase II enzymes indicated in the table below. Please feel free to call or e-mail us to discuss your specific requirements. The price we quote to you will depend upon: a) the complexity of the assay required, b) the number of alleles for which a genotype designation is needed and c) the number of patient samples. A full service, performed to BS EN ISO9001:2000, including sample tracking, DNA preparation, quantitation and storage, will be quoted if this is required by yourselves.

b. Regulatory Geneblitz® genotyping:

Our regulatory Geneblitz® genotyping service offers the additional option of assay validation to ICH guidelines Q2A and Q2B (specificity, accuracy, precision, detection limit and robustness). We develop the programme of work according to client's requirements and to an agreed project management schedule.

Phase I enzymes

Gene

Designated alleles

In house assay?

CYP1A1

*1A, B, C *2A, B, C *3 *4 *5 *6

Yes

CYP1A2

*1A to H *2 *3 *4 *5 *6

Yes

CYP1B1

*1 to *7 *11 to *26

Yes

CYP2A6

*1 *2 *3 *4A to D *5 to 11

Yes

CYP2B6

*1 to *7

Yes

CYP2C8

*1A, B, C, *2 *3 *4

Yes

CYP2C9

*1 to *6

Yes

CYP2C1

*1A, B *2A, B, *3, *4, *5A, B *6 to *8

Yes

CYP2D6

Please enquire

-

CYP2E1

*1 A to D *2 to *7

Yes

CYP2J2

*1 to *7

Yes

CYP3A4

Please enquire

-

CYP3A5

*1 to *7

Yes

CYP3A7

*1A to E

Yes

CYP4B1

*1 to *5

Yes

CYP5A1

*1 to *9

Yes

CYP8A1

*1A to L *2 *3 *4

Yes

CYP21

*1 to *59

Yes

Phase II enzymes

Gene

Designated alleles

In house assay?

GST-M1

Gene deletion
Gene duplication

Yes
Yes

GST-T1

Gene deletion

Yes

GST-P1

*A *B *C

Yes

NAT-1

*3 *4 *5 *10 *11 *14 to *29,

Yes

NAT-2

*4 *5 *6 *7 *10 to *14 *17 to *19

Yes

EPHX-1

Tyr 113 His

Yes

We also offer services such as Residual DNA, Genotyping, Forensic Testing, Gene Expression and various other services. Please click here to contact us with your requirements.

We are reliable, responsive and cost effective.